TSGA10 and H2AX competition over binding HIF-1 in breast cancer
نویسندگان
چکیده
منابع مشابه
lactobacilli modulate hypoxia-inducible factor (hif)-1 regulatory pathway in triple negative breast cancer cell line
objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...
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In a recent issue of PNAS, Zhang et al. (1) find that digoxin inhibits HIF-1 (a transcription factor highly involved in cancer development) and suggest that this effect might be observed in patients taking this drug. They also report that digoxin blocks tumor growth in mice (1). These data suggest that digoxin has anticancer potential. The authors observe that digoxin inhibits HIF-1 at 100 nM a...
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15 صفحه اولExpression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer
BACKGROUND Breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. Cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies. OBJECTIVES In this study we determined the expression of cancer testis genes Tsga10, TEX101 and ...
متن کاملexpression of testis specific genes tsga10, tex101 and odf3 in breast cancer
background breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies. objectives in this study we determined the expression of cancer testis genes tsga10, tex101 and od...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2019
ISSN: 0923-7534
DOI: 10.1093/annonc/mdz338.068